HBI-2375 (HYBI-084) is a selective, brain-penetrant and orally active MLL1-WDR5 interaction inhibitor. HBI-2375 inhibits WDR5 with an IC50 of 4.48 nM. HBI-2375 shows inhibition of proliferation in MV4,11 leukemia cells (IC50: 3.17 µM). HBI-2375 is capable of targeted disruption of histone methyltransferase activity in cancer cells. HBI-2375 can be used for the study of leukemia, glioma and glioblastoma[1][2].
Molecular Weight:
616.11
CAS Number:
[2982574-79-6]
Formula:
C29H36ClF2N9O2
Target:
Histone Methyltransferase,WDR5
Application Notes:
MCE Product type: Reference compound
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