MU876 (Compound 32) is a MUS81 inhibitor with an IC50 of 0.5 µM. MU876 effectively inhibits MUS81-dependent homologous recombination (HR) and break-induced replication (BIR) pathways. MU876 sensitizes cancer cells to DNA-damaging agents, such as Cisplatin (HY-17394), through impairing their ability to repair DNA lesions. MU876 can be used for cancers chemotherapy research[1].
Molecular Weight:
438.44
CAS Number:
[208829-24-6]
Formula:
C24H18N6O3
Target:
Endonuclease
Application Notes:
MCE Product type: Reference compound
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