MBL-II-141, CAS [[1353747-12-2]] Preis auf Anfrage

Product Overview

• Article Name: MBL-II-141, CAS [[1353747-12-2]] Preis auf Anfrage
• Biozol Catalog Number: MCE-HY-17648
• Supplier Catalog Number: HY-17648
• Alternative Catalog Number: MCE-HY-17648-1UNIT
• Manufacturer: MedchemExpress
• Category: Biochemikalien

Product Description

MBL-II-141 is potent ABCG2 inhibitor with an IC50 of 0.11 µM. MBL-II-141 inhibits the transport function of ABCG2 in a non-competitive manner, preventing ABCG2 from pumping substrates (such as Irinotecan (HY-16562)) out of the cells, thereby increasing the accumulation of drugs within the cells. MBL-II-141 has no effect on ABCB1 (P-gp) and ABCC1 (MRP1) and has extremely low cytotoxicity (IG50 > 100 µM). MBL-II-141 can be used for the study of multidrug resistance (MDR) cancers[1][2].

Product Properties

• Molecular Weight: 547.40
• CAS Number: [1353747-12-2]
• Formula: C28H23BrN2O5
• Target: BCRP

Application Notes

• Application Notes: MCE Product type: Reference compound