Mol4 (AK-918/41759663) is a highly selective BCL-2 protein inhibitor (IC50=153.3 µM). Mol4 induces mitochondrial outer membrane permeabilization (MOMP) and cytochrome c release, showing significant antiproliferative activity against glioblastoma (U87-MG) cell lines. Mol4 is promising for research of BCL-2-dependent tumors (e.g., chronic lymphocytic leukemia)[1].
Molecular Weight:
542.00
CAS Number:
[512800-53-2]
Formula:
C30H20ClNO5S
Target:
Bcl-2 Family
Application Notes:
MCE Product type: Reference compound
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