Naperiglipron (LY3549492) (Example 2) is a Glucagon-like peptide 1 receptor (GLP-1R) agonist with an EC50 of 1.14 nM for hGLP-1R. Naperiglipron significantly decreases the level of blood glucose in GLP-1R knock-in mouse models. Naperiglipron inhibits PDE10A1 enzyme activity (IC50: 7.43 µM) with a weak hERG inhibitory activity. Naperiglipron can be used for type II diabetes mellitus (T2DM) and obesity research[1].
Molecular Weight:
580.58
Purity:
99.43
CAS Number:
[2572566-11-9]
Formula:
C33H26F2N4O4
Target:
GLP Receptor,Phosphodiesterase (PDE)
Application Notes:
MCE Product type: Reference compound
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