VR11 aptamer is a DNA-based TNF-alpha inhibitor with a KD of 7.0 nM. VR11 aptamer prevents TNFalpha-induced apoptosis and NO production. VR11 aptamer has non-immunogenicity and does not raise immune responses when injected intraperitoneally into C57BL/6 mice model. VR11 aptamer can be used for inflammatory diseases research[1].
Target:
Apoptosis,NO Synthase,TNF Receptor
Application Notes:
MCE Product type: Oligonucleotides
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