RIPK1-IN-34, CAS [[3065634-19-4]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-178464
Supplier Catalog Number:
HY-178464
Alternative Catalog Number:
MCE-HY-178464-1UNIT
Manufacturer:
MedchemExpress
Category:
Biochemikalien
RIPK1-IN-34 is a selective, brain-penetrant RIPK1 inhibitor (IC50 = 126.70 nM) with almost no inhibitory effect on RIPK3 (IC50 > 10, 000 nM). RIPK1-IN-34 offers substantial neuroprotection by inhibiting the phosphorylation of RIPK1, RIPK3, and mixed lineage kinase domain-like pseudokinase (MLKL) within the necroptosis pathway. RIPK1-IN-34 shows the neuroprotective effect in a rat middle cerebral artery occlusion (MCAO) model. RIPK1-IN-34 can be used for the study of anti-acute ischemic stroke (AIS)[1].
Molecular Weight:
491.54
CAS Number:
[3065634-19-4]
Formula:
C28H25N7O2
Target:
Mixed Lineage Kinase,Necroptosis,RIP kinase
Application Notes:
MCE Product type: Reference compound
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