AMG-315 is a selective and potent CB1 agonist with a Ki of 7.8 nM and an EC50 of 0.6 nM. AMG-315 can significantly inhibit the cAMP production induced by Forskolin (HY-15371) with the maximum inhibitory effect reaching 76%. AMG-315 has significant stability against all endogenous cannabinoid hydrolases and oxidases. AMG-315 increases the mechanical withdrawal threshold in CFA (HY-153808)-induced inflammatory pain model. AMG-315 can be used for the research of inflammation[1].
Molecular Weight:
375.59
CAS Number:
[2244425-65-6]
Formula:
C24H41NO2
Target:
Cannabinoid Receptor
Application Notes:
MCE Product type: Reference compound1
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