PROTAC GPX4 degrader-5 is an efficient and highly selective GPX4 PROTAC degrader (DC50 = 28 nM). PROTAC GPX4 degrader-5 can induce ferroptosis and has low toxicity to normal cells. PROTAC GPX4 degrader-5 can significantly increase ROS. PROTAC GPX4 degrader-5 exerts anti proliferative effects on various tumor cells. PROTAC GPX4 degrader-5 is commonly used in cancer research. (Pink: GPX4 Ligand (HY-179294), Blue: Hyt Hydrophobic group (HY-N2427), Black: Linker (HY-W047688))[1]
Molecular Weight:
827.51
Formula:
C47H59ClN4O5S
Target:
Ferroptosis,Glutathione Peroxidase,PROTACs,Reactive Oxygen Species (ROS)
Application Notes:
MCE Product type: Reference compound
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