PROTAC DAPK1 Degrader-1 (Compound CP1) is a DAPK1 PROTAC degrader with a DC50 of 119.6 nM. PROTAC DAPK1 Degrader-1 significantly increased the MDM2 protein level. PROTAC DAPK1 Degrader-1 significantly reduced the levels of cleaved caspase-3 and cleaved PARP in a cell apoptosis model induced by the neurotoxin ceramide, indicating that it effectively inhibits neuronal apoptosis by degrading DAPK1. PROTAC DAPK1 Degrader-1 can be used to study neurological diseases such as cerebral ischemia and traumatic brain injury (pink: DAPK1 ligand (HY-179071), blue: CRBN ligand (HY-10984), black: linker (HY-40171))[1].
Molecular Weight:
657.66
Purity:
93.24
CAS Number:
[3063030-38-3]
Formula:
C30H27N9O7S
Target:
DAPK,PROTACs
Application Notes:
MCE Product type: Reference compound
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