PLK4-IN-5 (compound 5f) is a PLK4 (IC50 = 0.8 nM) inhibitor. PLK4-IN-5 can inhibit MCF-7 cell clone formation, induce cell cycle arrest (S/G2 phase), and apoptosis. PLK4-IN-5 has anti proliferative activity against MCF-7 cells (IC50 = 0.48 µM). PLK4-IN-5 can be used in the research of cancer such as breast cancer[1].
Molecular Weight:
476.01
Formula:
C21H22ClN5O2S2
Target:
Apoptosis,Polo-like Kinase (PLK)
Application Notes:
MCE Product type: Reference compound
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