CDK2-IN-49 (Compound 5j) is a CDK2 inhibitor with an IC50 of 0.25 µM. CDK2-IN-49 shows potent activity against CDK7 with an IC50 of 0.14 µM. CDK2-IN-49 induces Apoptosis by raising the levels of p53 and Bax protein expression while reducing the amount of Bcl-2. CDK2-IN-49 inhibits cell division. CDK2-IN-49 can be used in the research of cancer[1].
Molecular Weight:
358.40
Formula:
C20H18N6O
Target:
Apoptosis,Bcl-2 Family,CDK,MDM-2/p53
Application Notes:
MCE Product type: Reference compound1
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