3-Oxochol-5-en-24-oic acid, CAS [[847232-54-6]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-179476
Supplier Catalog Number:
HY-179476
Alternative Catalog Number:
MCE-HY-179476-1UNIT
Manufacturer:
MedchemExpress
Category:
Biochemikalien
3-Oxochol-5-en-24-oic acid is a rare bile acid produced by the intestinal microbiota. 3-Oxochol-5-en-24-oic acid is a potent antagonist of the human androgen receptor (hAR), with an IC50 of 119.4 nM. 3-Oxochol-5-en-24-oic acid has no significant agonistic or antagonistic effects on estrogen receptors (ER) or glucocorticoid receptors (GR). 3-Oxochol-5-en-24-oic acid effectively inhibits the growth of prostate cancer cells. In animal models, it enhances the efficacy of anti-PD-1 therapy by regulating the differentiation of CD8+ T cells. 3-Oxochol-5-en-24-oic acid can be used for research on regulating host immunity and anti-tumor studies[1].
Molecular Weight:
372.54
CAS Number:
[847232-54-6]
Formula:
C24H36O3
Target:
Androgen Receptor,Endogenous Metabolite
Application Notes:
MCE Product type: Natural Products
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