ZD-1-186 is a nondegradative molecular glue that potently suppresses MYC and robustly induces CDKN1A (p21) in diffuse large B-cell lymphoma cells. ZD-1-186 brings together BCL6 with BRD9, a noncanonical BAF complex bromodomain protein implicated in maintaining MYC transcriptional output in specific lymphoma contexts. ZD-1-186 can be used for targeted transcriptional rewiring research[1].
Molecular Weight:
750.24
Formula:
C35H37ClFN9O5S
Target:
c-Myc,Molecular Glues
Application Notes:
MCE Product type: Reference compound
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