G194-0712 is a selective histone deacetylase 5 (HDAC5) activator with an EC50 of 7.96 µM and a Kd of 2.53 µM. G194-0712 restores ACTN4-K417 deacetylation and nuclear import, and increases CSTA expression. G194-0712 accelerates wound closure in chronic wound models, reducing wound area and epithelial gap. G194-0712 can be used for the research of chronic skin wounds, such as diabetic wounds, ischemic wounds, radiation injury wounds[1].
Molecular Weight:
353.85
CAS Number:
[1029737-28-7]
Formula:
C20H20ClN3O
Target:
HDAC
Application Notes:
MCE Product type: Reference compound
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