ERK5-IN-7 is an orally active ERK5 inhibitor with an IC50 of 403.4 nM. ERK5-IN-7 directly inhibits ERK5 kinase activity, and downregulates the phosphorylation level and total protein expression of ERK5. ERK5-IN-7 induces Apoptosis (upregulates Bax, downregulates Bcl-2, and induces Caspase-3 cleavage). ERK5-IN-7 induces ROS accumulation. ERK5-IN-7 exhibits anticancer effects against Lewis lung cancer[1].
Molecular Weight:
373.24
Formula:
C18H14Cl2N4O
Target:
Apoptosis,Bcl-2 Family,Caspase,ERK,Reactive Oxygen Species (ROS)
Application Notes:
MCE Product type: Reference compound
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