Poltheta-IN-10, CAS [[3068829-46-6]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-181611
Supplier Catalog Number:
HY-181611
Alternative Catalog Number:
MCE-HY-181611-1UNIT
Manufacturer:
MedchemExpress
Category:
Biochemikalien
Poltheta-IN-10 is a Poltheta-pol inhibitor (with a human IC50 of 1.3 nM) that exhibits oral bioavailability in mice and rats. Poltheta-IN-10 binds to the allosteric site of Poltheta-pol, disrupts the microhomology-mediated end-joining DNA repair pathway, and inhibits CYP2C9 (IC50=1.63 µM). Poltheta-IN-10 selectively inhibits the proliferation of HR-deficient cancer cells and induces apoptosis. Poltheta-IN-10 is applicable to the research of HR-deficient cancers[1].
Molecular Weight:
556.51
CAS Number:
[3068829-46-6]
Formula:
C27H24F4N6O3
Target:
Apoptosis,Cytochrome P450,DNA/RNA Synthesis
Application Notes:
MCE Product type: Reference compound
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