EGFR-IN-200, CAS [[3102899-89-5]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-181657
Supplier Catalog Number:
HY-181657
Alternative Catalog Number:
MCE-HY-181657-1UNIT
Manufacturer:
MedchemExpress
Category:
Biochemikalien
EGFR-IN-200 is an inhibitor targeting EGFR, TNF-alpha, and the IL-6/GP130 complex, which potently targets human EGFR (IC50=0.03 µM), TNF-alpha (IC50=3.1 µM), and the IL-6/GP130 complex (IC50=1.6 µM). EGFR-IN-200 binds to the ATP pocket of EGFR, the trimer interface of TNF-alpha, and the cytokine-receptor interface of IL-6/GP130, induces G2/M cell cycle arrest, apoptosis, and antiproliferative activity. EGFR-IN-200 exhibits high gastrointestinal absorbability, low BBB permeability, and complies with the Lipinskis rule. EGFR-IN-200 can be used for the research of lung cancer and breast adenocarcinoma[1].
Molecular Weight:
499.94
CAS Number:
[3102899-89-5]
Formula:
C28H22ClN3O4
Target:
Apoptosis,EGFR,Interleukin Related,TNF Receptor
Application Notes:
MCE Product type: Reference compound
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