PROTAC HDAC3 degrader-1 is a selective PROTAC degrader targeting HDAC3 with a DC50 of 30.73 nM. PROTAC HDAC3 degrader-1 induces degradation of HDAC3 via the ubiquitin-proteasome system. PROTAC HDAC3 degrader-1 promotes apoptosis, induces DNA damage, and downregulates anti-apoptotic proteins Mcl-1 and Bcl-xL. PROTAC HDAC3 degrader-1 can be used for the research of acute myeloid leukemia[1].
Molecular Weight:
934.16
Formula:
C50H63N9O7S
Target:
Apoptosis,Bcl-2 Family,HDAC,PROTACs
Application Notes:
MCE Product type: Reference compound
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