Telomeric G4s ligand 2, CAS [[3094716-52-3]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-181850
Supplier Catalog Number:
HY-181850
Alternative Catalog Number:
MCE-HY-181850-1UNIT
Manufacturer:
MedchemExpress
Category:
Biochemikalien
Telomeric G4s ligand 2 is an orally active, selective ligand of telomeric G-quadruplex (G4), with an IC50 of 0.4 µM. Telomeric G4s ligand 2 binds to dimeric telomeric G4, inhibits the activities of DHX36 and BLM helicases. Telomeric G4s ligand 2 activates cGAS-STING and TERRA-ZBP1 pathways, inducing autophagy and G2/M cell cycle arrest, and exhibits antiproliferative effects across cancer cell lines. Telomeric G4s ligand 2 can be used for the study of colorectal cancer[1].
