KRAS G12C-IN-78, CAS [[3023465-20-2]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-181965
Supplier Catalog Number:
HY-181965
Alternative Catalog Number:
MCE-HY-181965-1UNIT
Manufacturer:
MedchemExpress
Category:
Biochemikalien
KRAS G12C-IN-78 is a selective SWII-binding KRASG12C dual inhibitor targeting both inactive and active states. KRAS G12C-IN-78 rapidly inhibits ERK1/2 phosphorylation, induces covalent adduct formation with endogenous KRASG12C, suppresses MAPK pathway gene expression, and inhibits cellular proliferation in KRASG12C mutant cells. KRAS G12C-IN-78 can be used for the research of KRASG12C mutant solid tumors, including pancreatic ductal adenocarcinoma and non-small cell lung cancer[1].
Molecular Weight:
729.75
CAS Number:
[3023465-20-2]
Formula:
C37H31F4N7O3S
Target:
ERK,p38 MAPK,Ras
Application Notes:
MCE Product type: Reference compound
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