Atopaxar hydrochloride (E5555 hydrochloride) is the hydrochloride salt form of Atopaxar (HY-18200). Atopaxar hydrochloride is an orally active, selective and reversible antagonist for thrombin receptor protease-activated receptor-1 (PAR-1). Atopaxar hydrochloride is the inhibitor for Janus kinase 1 (JAK1) and JAK2, which inhibits the JAK-STAT with EC50 of 5.90 µM in A549. Atopaxar hydrochloride inhibits the cell viability of A549 (IC50=7.02 µM), arrests the cell cycle at G1 phase and induces apoptosis. Atopaxar hydrochloride exhibits antiplatelet and antitumor activities. Atopaxar hydrochloride can be used for the research of atherothrombotic disease[1][2][3].
Molecular Weight:
564.09
CAS Number:
[474544-83-7]
Formula:
C29H39ClFN3O5
Target:
Apoptosis,JAK,Protease Activated Receptor (PAR)
Application Notes:
MCE Product type: Reference compound
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