FXR agonist 17, CAS [[3107769-23-0]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-182026
Supplier Catalog Number:
HY-182026
Alternative Catalog Number:
MCE-HY-182026-1UNIT
Manufacturer:
MedchemExpress
Category:
Biochemikalien
FXR agonist 17 is an orally active, steroidal FXR agonist with EC50 values of 42.2 nM (TR-FRET) and 176.4 nM (luciferase reporter assay), respectively. FXR agonist 17 activates TGR5 (EC50 = 2.6 µM) but does not activate hMRGPRX4. FXR agonist 17 exerts anti-inflammatory, hepatoprotective and antifibrotic effects, improves the non-alcoholic steatohepatitis (NAFLD) activity score and reduces the severity of liver fibrosis. FXR agonist 17 can be used for the research of NAFLD, cholestatic liver disease and liver fibrosis[1].
Molecular Weight:
502.75
CAS Number:
[3107769-23-0]
Formula:
C29H46N2O3S
Target:
FXR,G protein-coupled Bile Acid Receptor 1,Reactive Oxygen Species (ROS),TNF Receptor
Application Notes:
MCE Product type: Reference compound
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