TGF-beta1/Smad3-IN-2 is an orally effective antifibrotic agent. TGF-beta1/Smad3-IN-2 has high affinity for VDR and can inhibit the TGFbeta/SMAD3 signaling pathway. TGF-beta1/Smad3-IN-2 inhibits hepatic stellate cell activation, reduces extracellular matrix deposition, and alleviates liver fibrosis in a bile duct ligation mouse model. TGF-beta1/Smad3-IN-2 can be used for the research of liver fibrosis[1].
Molecular Weight:
565.78
Formula:
C38H47NO3
Target:
TGF-beta/Smad,VD/VDR
Application Notes:
MCE Product type: Reference compound
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