Bax activator-2, CAS [[3034297-25-8]] Preis auf Anfrage

Product Overview

• Article Name: Bax activator-2, CAS [[3034297-25-8]] Preis auf Anfrage
• Biozol Catalog Number: MCE-HY-182349
• Supplier Catalog Number: HY-182349
• Alternative Catalog Number: MCE-HY-182349-1UNIT
• Manufacturer: MedchemExpress
• Category: Biochemikalien

Product Description

Bax activator-2 (compound 27c) is a pro-apoptotic agent targeting BAX, with an IC50 of 0.30 µmol/L against human BAX. Bax activator-2 binds to the trigger site of BAX and induces its conformational change. Bax activator-2 induces mitochondrial depolarization, cytochrome c release, caspase-3/9 cleavage and PARP cleavage, thereby initiating apoptosis. Bax activator-2 exhibits cytotoxicity against various cancer cell lines, shows reduced cytotoxicity in BAX-knockout A549 cells, and has low cytotoxicity against non-cancerous cell lines. Bax activator-2 can be used in studies related to acute myeloid leukemia and solid tumors[1].

Product Properties

• Molecular Weight: 505.52
• CAS Number: [3034297-25-8]
• Formula: C30H23N3O5
• Target: Bcl-2 Family

Application Notes

• Application Notes: MCE Product type: Reference compound