FJ9 is a NHERF1/PDZ inhibitor with human NHERF1 PDZ1 IC50 1540 µM, NHERF1 PDZ2 IC50 160 µM, and Frizzled-7-Dishevelled PDZ complex Ki 10 µM. FJ9 binds ligand-binding pockets of NHERF1 PDZ domains to block cognate ligand interactions, disrupts Frizzled-7-Dishevelled interactions, and down-regulates canonical Wnt signaling. FJ9 induces apoptosis in cancer cells with intact beta-catenin signaling. FJ9 can be used for the research of non-small cell lung cancer, melanoma[1][2].
Molecular Weight:
365.47
CAS Number:
[873841-43-1]
Formula:
C23H27NO3
Target:
Apoptosis,Na+/H+ Exchanger (NHE),Wnt
Application Notes:
MCE Product type: Reference compound
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