PSB-16671 is an allosteric agonist of GPR84. PSB-16671 recruits beta-arrestins and couples to Gi, enhances the Gi activation potency of orthosteric agonists, and exerts a synergistic effect with orthosteric agonists. PSB-16671 promotes G protein activation and partial chemotaxis independent of GPR84 in mouse neutrophils, maintains the phagocytic function of macrophages against cancer cells without inducing receptor desensitization. PSB-16671 can be used in cancer-related research[1][2][3].
Molecular Weight:
318.27
CAS Number:
[2094630-35-8]
Formula:
C17H10F4N2
Target:
GPR84
Application Notes:
MCE Product type: Reference compound1
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