KRAS-IN-58 is a KRAS inhibitor with a IC50 of 0.223 µM against KRASG12D. KRAS-IN-58 binds to KRASG12C and KRASG12D proteins, and reduces the levels of phosphorylated Raf1, AKT and ERK in pancreatic cancer cells. KRAS-IN-58 can be used for the research of pancreatic cancer[1].
Molecular Weight:
451.52
Formula:
C21H17N5O3S2
Target:
Akt,ERK,Raf,Ras
Application Notes:
MCE Product type: Reference compound
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