EZM8266 is an orally active and selective G9a (EHMT2) histone methyltransferase inhibitor with a human EHMT2 IC50 of 1 pM. EZM8266 reduces repressive H3K9me2 marks at immune-stimulatory gene and endogenous retroviral element promoters. EZM8266 reduces colony formation, migration, and invasion of cancer cells. EZM8266 enhances IFN-gamma response, increases MHC class I expression, and enhances CXCL10-mediated T cell recruitment in cancer cells. EZM8266 can be used for the research of hepatocellular carcinoma[1][2].
Molecular Weight:
373.45
CAS Number:
[2140164-84-5]
Formula:
C19H27N5O3
Target:
Histone Methyltransferase
Application Notes:
MCE Product type: Reference compound
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