Androgen receptor antagonist-14 (Compound S-94) is a selective antagonist of the T878A mutant androgen receptor (AR) with an IC50 of 0.38 µM. Androgen receptor antagonist-14 selectively antagonizes the transcriptional activity of the ART878A, ARF877L/T878A and ARH875Y/T878A mutant androgen receptors. Androgen receptor antagonist-14 exhibits anticancer activity against prostate cancer. Androgen receptor antagonist-14 can be used in the research of prostate cancer[1].
Molecular Weight:
427.50
Formula:
C26H25N3O3
Target:
Androgen Receptor
Application Notes:
MCE Product type: Reference compound
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