SHIP1-IN-1, CAS [[3027375-00-1]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-183593
Supplier Catalog Number:
HY-183593
Alternative Catalog Number:
MCE-HY-183593-1UNIT
Manufacturer:
MedchemExpress
Category:
Biochemikalien
SHIP1-IN-1 is an orally active, blood-brain barrier-permeable SHIP1 ligand. SHIP1-IN-1 exhibits IC50 values of 384 µM and 177 µM against human SHIP1, and an IC50 value of 379 µM against murine SHIP1. SHIP1-IN-1 alters the binding state of SHIP1 to phosphatidylinositol membranes, and regulates phosphoinositide pools and phosphorylated AKT levels. SHIP1-IN-1 enhances the uptake of myelin/membrane fragments and amyloid proteins by microglia, alters gene expression and reduces IL-1beta levels. SHIP1-IN-1 can be used in studies related to Alzheimers disease[1][2].
Molecular Weight:
368.86
CAS Number:
[3027375-00-1]
Formula:
C20H21ClN4O
Target:
Akt,Interleukin Related,Phosphatase
Application Notes:
MCE Product type: Reference compound
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