KT109 is a potent and an isoform-selective inhibitor of diacylglycerol lipase-beta (DAGLbeta) with an IC50 of 42 nM. KT109 has ~60-fold selectivity for DAGLbeta over DAGLalpha. KT109 shows inhibitory activity against PLA2G7 (IC50=1 µM). KT109 shows negligible activity against FAAH, MGLL, ABHD11, and cytosolic phospholipase A2 (cPLA2 or PLA2G4A). KT109 perturbs a lipid network involved in macrophage inflammatory responses and lowers 2-Arachidonoylglycerol (HY-W011051), Arachidonic acid (HY-109590) and eicosanoids in mouse peritoneal macrophages[1].
Molecular Weight:
422.52
Purity:
99.86
CAS Number:
[1402612-55-8]
Formula:
C27H26N4O
Target:
DAGL,MAGL
Application Notes:
MCE Product type: Reference compound
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