(rac)-ZK-304709, CAS [[1010440-84-2]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-19471
Supplier Catalog Number:
HY-19471
Alternative Catalog Number:
MCE-HY-19471-1UNIT
Manufacturer:
MedchemExpress
Category:
Biochemikalien
(rac)-ZK-304709 is an isoform of ZK-304709 and is an orally active multi-targeted tumor growth inhibitor that inhibits multiple cell cycle-dependent kinases (CDKs), vascular endothelial growth factor receptor kinases (VEGF-RTKs), and platelet-derived growth factor receptor kinase beta (PDGF-RTKbeta). (rac)-ZK-304709 can dose-dependently inhibit the proliferation and colony formation of neuroendocrine tumor (NET) cells. (rac)-ZK-304709 directly acts on NET cells by inducing G2 cell cycle arrest and apoptosis, while reducing the expression of MCL1, survivin, and HIF1alpha. (rac)-ZK-304709 effectively controls tumor growth by inducing apoptosis and inhibiting tumor-induced angiogenesis, and may become a potential agent for inhibiting NET[1].
Molecular Weight:
444.96
CAS Number:
[1010440-84-2]
Formula:
C22H29ClN6O2
Target:
Apoptosis,CDK,Drug Isomer,Survivin,VEGFR
Application Notes:
MCE Product type: Reference compound
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