THS-044 is a modulator of the formation of the HIF2alpha/ARNT heterodimer. THS-044 binding stabilizes the HIF2alpha PAS-B folded state (KD = 2 µM), for regulating HIF2 activity in endogenous and pathological settings, and does not bind to HIF1alpha or ARNT PAS-B. THS-044 increases the KD of the heterodimer formed by HIF2alpha PAS-B and ARNT PAS-B from 120 µM to 400 µM. THS-044 can be used for the study of diseases related to hypoxia[1][2].
Molecular Weight:
291.23
Purity:
99.67
CAS Number:
[62054-67-5]
Formula:
C11H12F3N3O3
Target:
HIF/HIF Prolyl-Hydroxylase
Application Notes:
MCE Product type: Reference compound
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