LY2775240 is an orally available phosphodiesterase 4 (PDE4) inhibitor with potent inhibitory activity against PDE4A (IC50 = 0.09 nM), PDE4B (IC50 = 0.09 nM), and PDE4D (IC50 = 0.14 nM), and exhibits an IC50 of 2.4 nM against PDE4C. LY2775240 is a highly selective agent that reduces TNFalpha production during immune activation. It effectively lowers TNFalpha levels in rodent and cynomolgus monkey models. LY2775240 can be used in research on psoriasis[1].
Molecular Weight:
485.58
CAS Number:
[1628160-15-5]
Formula:
C26H35N3O6
Target:
Phosphodiesterase (PDE),TNF Receptor
Application Notes:
MCE Product type: Reference compound1
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