Avagacestat (BMS-708163) is a potent inhibitor of gamma-secretase, with IC50s of 0.27 nM and 0.30 nM for Abeta42 and Abeta40 inhibition, Avagacestat (BMS-708163) also inhibits NICD (Notch IntraCellular Domain) with IC50 of 0.84 nM and shows weak inhibition of CYP2C19, with IC50 of 20 µM. Avagacestat can be used for Alzheimer disease research.
Molecular Weight:
520.89
Purity:
99.92
CAS Number:
[1146699-66-2]
Formula:
C20H17ClF4N4O4S
Target:
Notch,gamma-secretase
Application Notes:
MCE Product type: Reference compound1
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