Crizotinib (PF-02341066) is an orally bioavailable, ATP-competitive ALK and c-Met inhibitor with IC50s of 20 and 8 nM, respectively. Crizotinib inhibits tyrosine phosphorylation of NPM-ALK and tyrosine phosphorylation of c-Met with IC50s of 24 and 11 nM in cell-based assays, respectively. Crizotinib is also a ROS1 inhibitor. Crizotinib has effective tumor growth inhibition[1][2][3].
Molecular Weight:
450.34
Purity:
99.97
CAS Number:
[877399-52-5]
Formula:
C21H22Cl2FN5O
Target:
Anaplastic lymphoma kinase (ALK),c-Met/HGFR,Ligands for Target Protein for PROTAC,ROS Kinase
Application Notes:
MCE Product type: Reference compound
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