Crizotinib-d5, CAS [[1395950-84-1]]

Product Overview

• Article Name: Crizotinib-d5, CAS [[1395950-84-1]]
• Biozol Catalog Number: MCE-HY-50878S
• Supplier Catalog Number: HY-50878S
• Alternative Catalog Number: MCE-HY-50878S-1MG
• Manufacturer: MedchemExpress
• Category: Biochemikalien
• Alternative Names: PF-02341066-d5

Product Description

Crizotinib-d5 is the deuterium labeled Crizotinib. Crizotinib (PF-02341066) is an orally bioavailable, ATP-competitive ALK and c-Met inhibitor with IC50s of 20 and 8 nM, respectively. Crizotinib inhibits tyrosine phosphorylation of NPM-ALK and tyrosine phosphorylation of c-Met with IC50s of 24 and 11 nM in cell-based assays, respectively. Crizotinib is also a ROS1 inhibitor. Crizotinib has effective tumor growth inhibition[1][2][3].

Product Properties

• Molecular Weight: 455.37
• Purity: 99.7
• CAS Number: [1395950-84-1]
• Formula: C21H17D5Cl2FN5O
• Target: Anaplastic lymphoma kinase (ALK),Autophagy,c-Met/HGFR,ROS Kinase

Application Notes

• Application Notes: MCE Product type: Isotope-Labeled Compounds