ABT-737, a BH3 mimetic, is a potent Bcl-2, Bcl-xL and Bcl-w inhibitor with EC50s of 30.3 nM, 78.7 nM, and 197.8 nM, respectively. ABT-737 induces the disruption of the BCL-2/BAX complex and BAK-dependent but BIM-independent activation of the intrinsic apoptotic pathway. ABT-737 induces autophagy and has the potential for acute myeloid leukemia (AML) research[1][2][3].
Molecular Weight:
813.43
Purity:
99.64
CAS Number:
[852808-04-9]
Formula:
C42H45ClN6O5S2
Target:
Apoptosis,Autophagy,Bcl-2 Family,Mitophagy
Application Notes:
MCE Product type: Reference compound
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