Pevonedistat (MLN4924) is a potent and selective NEDD8-activating enzyme (NAE) inhibitor with an IC50 of 4.7 nM. Pevonedistat induces the deregulation of S-phase DNA synthesis, thereby disrupting protein turnover mediated by cullin-RING ligase, leading to apoptosis of human tumor cells. Pevonedistat suppresses the growth of human tumour xenografts in mice[1].
Molecular Weight:
443.52
Purity:
99.98
CAS Number:
[905579-51-3]
Formula:
C21H25N5O4S
Target:
Apoptosis,NEDD8-activating Enzyme
Application Notes:
MCE Product type: Reference compound
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