Hydrastine ((-)-beta-Hydrastine, (1R,9S)-beta-Hydrastine) is a selective competitive inhibitor of tyrosine hydroxylase (TH), inhibiting dopamine biosynthesis (IC50=20.7 µM, PC12 cells). Hydrastine also inhibits the organic cation transporter OCT1 (IC50=6.6 µM). Hydrastine may cause neuronal toxicity through mitochondrial dysfunction rather than oxidative stress damage, and can aggravate cell apoptosis when combined with L-DOPA. Hydrastine can be used to study Parkinsons disease-related dopaminergic neuronal damage[1][2].
Molecular Weight:
383.39
Purity:
99.57
CAS Number:
[118-08-1]
Formula:
C21H21NO6
Target:
Dopamine Receptor,OAT,Tyrosine Hydroxylase
Application Notes:
MCE Product type: Natural Products
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