Mollugin is an orally active and potent NF-kappaB inhibitor. Mollugin induces S-phase arrest of HepG2 cells, and increased intracellular reactive oxygen species (ROS) levels. Mollugin induces DNA damage in HepG2 cells, as well as an increase in the expression of p-H2AX. Mollugin shows anti-cancer effect by inhibiting TNF-alpha-induced NF-kappaB activation. Mollugin enhances the osteogenic action of BMP-2 (bone morphogenetic protein 2) via the p38-Smad signaling pathway[1][2][3].
Molecular Weight:
284.31
Purity:
99.79
CAS Number:
[55481-88-4]
Formula:
C17H16O4
Target:
Apoptosis,c-Myc,JAK,NF-kappaB,Reactive Oxygen Species (ROS),VEGFR
Application Notes:
MCE Product type: Natural Products
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