8-O-Acetylharpagide is an iridoid glycoside compound. 8-O-Acetylharpagide exhibits anti-aging activity at low doses and anticancer activity at high doses. 8-O-Acetylharpagide induces late-stage apoptosis and necrosis-like death in cancer cells, and downregulates anti-apoptotic proteins such as Akt, p-Akt and Bcl-2. 8-O-Acetylharpagide is mainly metabolized in rats via demethylation, hydrolysis and glucuronidation, and its active metabolites downregulate the AKT/NF-kappaB/MMP9 signaling axis. 8-O-Acetylharpagide exerts vasoconstrictive effects by activating vascular alpha-adrenoceptor[1][2][3].
Molecular Weight:
406.38
Purity:
99.75
CAS Number:
[6926-14-3]
Formula:
C17H26O11
Target:
Adrenergic Receptor,Akt,Apoptosis,Bcl-2 Family
Application Notes:
MCE Product type: Natural Products
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