Notoginsenoside R2 (20(S)-Notoginsenoside R2, Ginsenoside Ng-R2) is an orally active notoginsenoside. Notoginsenoside R2 activates P90RSK and Nrf2 via the MEK1/2-ERK1/2 pathway to inhibit 6-OHDA-induced apoptotic damage in nerve cells. Notoginsenoside R2 upregulates SOX8/beta-catenin by reducing miR-27a, thereby suppressing Abeta25-35-induced neuronal apoptosis and inflammatory responses. Notoginsenoside R2 alleviates lipid accumulation and mitochondrial dysfunction in diabetic nephropathy by inhibiting c-Src. Notoginsenoside R2 alleviates hepatic fibrosis by inducing hepatic stellate cell senescence and inhibiting the inflammatory microenvironment via JAK/STAT3 suppression. Notoginsenoside R2 can be used in research related to Parkinsons disease, Alzheimers disease, diabetic nephropathy and hepatic fibrosis[1][2][3][4][5].
Molecular Weight:
770.99
Purity:
99.80
CAS Number:
[80418-25-3]
Formula:
C41H70O13
Target:
Apoptosis,Caspase,COX,ERK,JAK,MDM-2/p53,MEK,Reactive Oxygen Species (ROS),Src,STAT,beta-catenin
Application Notes:
MCE Product type: Natural Products
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