Chrysosplenetin is one of the polymethoxylated flavonoids in Artemisia annua L. (Compositae) and other several Chinese herbs. Chrysosplenetin inhibits P-gp activity and reverses the up-regulated P-gp and MDR1 levels induced by artemisinin (ART). Chrysosplenetin significantly augments the rat plasma level and anti-malarial efficacy of ART, partially due to the uncompetitive inhibition effect of Chrysosplenetin on rat CYP3A[1].
Molecular Weight:
374.34
Purity:
99.68
CAS Number:
[603-56-5]
Formula:
C19H18O8
Target:
Cytochrome P450,Ferroptosis,P-glycoprotein
Application Notes:
MCE Product type: Natural Products
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