Lotusine is an orally active signaling pathway modulator and enzyme inhibitor, with an IC50 of 30.60 µg/mL against alpha-amylase and an IC50 of 36.15 µg/mL against alpha-glucosidase. Lotusine inhibits the EGFR-Akt-ERK signaling pathway by reducing the levels of phosphorylated EGFR, Akt and ERK. Lotusine induces apoptosis, triggers G0/G1 cell cycle arrest and inhibits cancer cell proliferation. Lotusine reduces lipid peroxidation and increases the activities of SOD, CAT and GPx. Lotusine is applicable to researches related to non-small cell lung cancer, type 2 diabetes and autism spectrum disorder[1][2][3][4].
Molecular Weight:
314.40
Purity:
99.91
CAS Number:
[6871-67-6]
Formula:
C19H24NO3
Target:
Amylases,Glycosidase
Application Notes:
MCE Product type: Natural Products
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