Dehydromonocrotaline is a mitochondrial respiratory chain complex I NADH oxidase inhibitor, with a IC50 of 62.06 µM and a Ki of 8.1 µM in rats. Dehydromonocrotaline exerts non-competitive inhibitory effects by modifying cysteine thiol groups on complex I, and does not bind to the NADH-binding site. Dehydromonocrotaline dissipates mitochondrial membrane potential and reduces ATP levels. Dehydromonocrotaline can be used in studies related to hepatotoxicity, pulmonary hypertension and liver tumors[1][2][3].
Molecular Weight:
323.34
CAS Number:
[23291-96-5]
Formula:
C16H21NO6
Target:
Endogenous Metabolite
Application Notes:
MCE Product type: Natural Products
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