beta-Sheet Breaker Peptide iAbeta5, CAS [[182912-74-9]]
Biozol Catalog Number:
MCE-HY-P1047
Supplier Catalog Number:
HY-P1047
Alternative Catalog Number:
MCE-HY-P1047-5MG,MCE-HY-P1047-10MG
Manufacturer:
MedchemExpress
Category:
Proteine/Peptide
Alternative Names:
[Pro18, Asp21] beta-Amyloid (17-21)
beta-Sheet Breaker Peptide iAbeta5 is an effective brain amyloid-beta (Abeta) degrader. Abeta deposits are associated with Alzheimers disease (AD), and the related toxicity arises from its beta-sheet conformation and aggregation. beta-Sheet Breaker Peptide iAbeta5 can repeatedly induce the degradation of fibrillary amyloid deposits in vivo. Therefore, beta-Sheet Breaker Peptide iAbeta5 can prevent and/or reverse neuronal contraction caused by Abeta and reduce the range of interleukin IL-1beta positive microglial-like cells around Abeta deposits. beta-Sheet Breaker Peptide iAbeta5 can reduce the size and/or number of brain amyloid plaques in AD. beta-Sheet Breaker Peptide iAbeta5 is labeled with a hydrophobic benzyl alcohol (HBA) tag and shows a bright blue color under acidic conditions, which can be used for quantitative determination.
Molecular Weight:
637.72
Purity:
99.92
CAS Number:
[182912-74-9]
Formula:
C33H43N5O8
Target:
Amyloid-beta
Application Notes:
Peptides
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