Guanidino-G-Clamp-PNA, CAS [[476667-31-9]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-P11698
Supplier Catalog Number:
HY-P11698
Alternative Catalog Number:
MCE-HY-P11698-1UNIT
Manufacturer:
MedchemExpress
Category:
Proteine/Peptide
Guanidino-G-Clamp-PNA is a highly efficient sequence-specific RNA binder and gene silencer. Guanidino-G-Clamp-PNA precisely targets such targets as miR-155 or transthyretin (TTR) mRNA through base pairing: the former regulates tumor-related signaling pathways by reducing microRNA activity, while the latter inhibits the translation of harmful proteins via steric hindrance. Guanidino-G-Clamp-PNA effectively stabilizes DNA/RNA duplexes, induces cancer cell apoptosis, and suppresses tumor growth. In addition, Guanidino-G-Clamp-PNA can be conjugated with targeting ligands to improve tissue-specific delivery and reduce in vivo adverse reactions, and it can also enhance the splicing regulation efficacy of other oligonucleotide platforms (such as PMO) when integrated into them. Guanidino-G-Clamp-PNA is applicable to the research of various diseases including diffuse large B-cell lymphoma and hereditary transthyretin-related amyloidosis[1][2].
Molecular Weight:
950.95
CAS Number:
[476667-31-9]
Formula:
C50H46N8O12
Target:
DNA Alkylator/Crosslinker,Transthyretin (TTR)
Application Notes:
MCE Product type: Peptides
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