PR-39, a natural proline- and arginine-rich antibacterial peptide, is a noncompetitive, reversible and allosteric proteasome inhibitor. PR-39 reversibly binds to the alpha7 subunit of the proteasome and blocks degradation of NF-kappaB inhibitor IkappaBalpha by the ubiquitin-proteasome pathway. PR-39 stimulates angiogenesis, inhibits inflammatory responses and significant reduces myocardial infarct size in mice[1][2].
Molecular Weight:
4719.74
CAS Number:
[139637-11-9]
Formula:
C229H346N70O40
Target:
Bacterial,Proteasome
Application Notes:
MCE Product type: Peptides
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